Comparative studies of high-throughput biological graphs

Systematic Interpretation of High-Throughput Biological Data

Measuring Reproductibility of High-Throughput Biological Experiments

Reproducibility is essential to reliable scientific discovery in large-scale high-throughput biological studies. In this talk, I will present a unified approach to measure reproducibility of findings identified from replicate experiments and select discoveries using reproducibility between replicates. Unlike the usual scalar measures of reproducibility, our approach views reproducibility as whe...

comparative dna interaction studies of antiviral drug, zidovudine and its complex using different instrumental methods

هدف از این مطالعه بررسی امکان استفاده از داروهای شناخته شده در درمان سایر بیماریها به عنوان داروهای ضد سرطان است. همچنین با استفاده از این داروها در ساختمان کمپلکس فلز می توان شاخص های دارویی بدست آمده را بررسی نمود. داروی ضد ویروس ایدز(hiv)به نام زیدوودین(azt)انتخاب و.کمپلکس.محلول.در.آب[pt(azt)2]cl2سنتزو به روشهای مختلف فیزیکی و شیمیایی شناسایی گردید. بر هم کنش مقایسه ای این دارو و کمپلکس پلا...

Statistical Methods for High-Throughput Biological Data

The explosion in DNA microarray technology in the last decade has given rise to extensive biological data in the form of expression profiles of tens of thousands of genes and proteins, often from only a handful of tissue samples. The principal objective of a high-throughput experiment can be generally characterized as one of class comparison, class prediction or molecular pattern discovery. Cla...

Droplet microfluidics for high-throughput biological assays.

Droplet microfluidics offers significant advantages for performing high-throughput screens and sensitive assays. Droplets allow sample volumes to be significantly reduced, leading to concomitant reductions in cost. Manipulation and measurement at kilohertz speeds enable up to 10(8) samples to be screened in one day. Compartmentalization in droplets increases assay sensitivity by increasing the ...